Matthew Ykema

A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses

This paper develops a bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses, showing it induces robust immune responses and complete protection in animal models.

Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus

This paper develops a replicon vaccine against H5N1 influenza that can be administered intranasally or intramuscularly, showing efficacy in reducing morbidity and mortality in a ferret model.

An intranasal, NLC-delivered self-amplifying RNA vaccine establishes protective immunity against pre-pandemic H5N1 and H7N9 influenza

An intranasal self-amplifying RNA vaccine delivered via nanostructured lipid carriers induces mucosal immunity and protects against H5N1 and H7N9 influenza in ferrets.