The ID93 + GLA-3M-052-LS vaccine candidate elicits mucosal and systemic immunogenicity and protective efficacy against Mycobacterium tuberculosis challenge in BCG-primed Collaborative Cross inbred mice
Emily A. Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine F. Jennewein, Devin S. Brandt, Susan Xiaoqin Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi Bertran Torrelles, Gillian Beamer, Christopher B. Fox
This study evaluates a TB vaccine candidate, ID93 + GLA-3M-052-LS, showing enhanced mucosal and systemic immunity and protection against Mtb in BCG-primed mice.
bioRxiv · Oct 31, 2025 · PreprintImmunology