Wendy Jean Mack

This study shows that metal-rich air pollutants induce ferroptosis and amyloidogenic pathways linked to Alzheimer's disease through shared transcriptional and oxidative mechanisms.

The paper examines apoE glycosylation in CSF and plasma samples from ADNI, finding reduced glycosylation in MCI and progressors, and associations with AD biomarkers like t-tau, p-tau181, and Aβ1-42.

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

This study examines the relationship between perivascular space characteristics, sleep, and brain functional connectivity in healthy aging individuals, finding correlations between PVS volume fraction and specific brain regions.

This study examines the relationship between sleep, walking, and cognition in Parkinson's disease, finding that walking difficulties directly impact cognition, while PVS does not mediate these associations.

The paper investigates iron-mediated toxicity in Alzheimer's disease by analyzing postmortem brain tissue and ApoE4 mice, finding increased lipid peroxidation and decreased antioxidants in lipid rafts, which are reduced by iron chelation.

This study examines the relationship between perivascular spaces, cortisol, hypertension, and inflammation in cognitive impairment, finding significant associations and interactions.

The paper shows that early cognitive dysfunction is associated with altered perivascular space presence and distribution, linked to tau tangle deposition in Alzheimer's disease pathology.