Lulu Shang

Paralemmin 2 is a shared, alternatively-spliced regulator of axon initial segments and paranodal junctions in oligodendrocytes

This study identifies Paralemmin 2 as a lipid raft-associated protein that regulates axon initial segments and paranodal junctions through cell type-specific splicing.

Optimal transport modeling uncovers spatial domain dynamics in spatiotemporal transcriptomics studies

SpaDOT identifies spatial domains and their temporal dynamics in spatiotemporal transcriptomics data, revealing key developmental processes like valvulogenesis.

Multi-ancestry transcriptome-wide association studies of cognitive function, white matter hyperintensity, and Alzheimer's disease

This paper conducts multi-ancestry transcriptome-wide association studies to identify genes associated with cognitive function, white matter hyperintensity, and Alzheimer's disease using gene expression data from European and African ancestry individuals.

Spatially Aware Dimension Reduction for Spatial Transcriptomics

This paper introduces SpatialPCA, a spatially-aware dimension reduction method for spatial transcriptomics, enabling analysis with existing single-cell tools and revealing new biological insights in tumor and neuronal contexts.

Leveraging Gene Co-expression Patterns to Infer Trait-Relevant Tissues in Genome-wide Association Studies

This paper introduces CoCoNet, a method that integrates GWAS data with gene co-expression networks to identify trait-relevant tissues and cell types, showing its application in neurological and autoimmune diseases.