Bodo Laube

Chromatin remodelling subunit SMARCB1 is implicated in dendrite development and complex brain functions

This study investigates the role of SMARCB1 in brain function and structure using a mouse model and human patients, finding deficits in motor coordination, spatial memory, and dendritic morphology.

Chromatin organization controls nuclear stiffness

The paper shows MeCP2 increases nuclear stiffness during differentiation, and this effect is disrupted by Rett syndrome mutations, correlating with disease severity.

Analysis of M4 transmembrane domains in NMDA receptor function: a negative allosteric modulation site at the GluN1 M4 is determining the efficiency of neurosteroid modulation

This study investigates the role of the M4 transmembrane domain in NMDA receptor function, showing that its deletion leads to nonfunctional receptors, but functional rescue is possible with isolated M4 peptides, and that M4 interfaces are critical for neurosteroid modulation.

Gating the channel pore of ionotropic glutamate receptors with bacterialsubstrate binding proteins

This study shows bacterial binding proteins can functionally replace parts of ionotropic glutamate receptors, demonstrating their modular evolution.