Chromatin organization controls nuclear stiffness
Hector Romero, Anahid Amiri, Maruthi Kumar Pabba, Hui Zhang, Veronika Berg, Maria Arroyo, Paulina Prorok, Nina Trautwein, Bodo Laube, Christian Dietz, Robert W. Stark, M. Cristina Cardoso
The paper shows MeCP2 increases nuclear stiffness during differentiation, and this effect is disrupted by Rett syndrome mutations, correlating with disease severity.
bioRxiv · Mar 14, 2025 · PreprintCell Biology