This study investigates the roles of CD47 on epithelial cells and γδ T cells in regulating γδ IEL migration, finding complementary yet distinct functions.

bioRxiv · Aug 24, 2026 · PreprintImmunology

The Protein Tyrosine Phosphatase CD45 promotes PMN Transepithelial Migration, Antimicrobial Function and Colonic Mucosal Repair

Jael Miranda, Dylan Fink, Zachary S. Wilson, Roland Hilgarth, Asma Nusrat, Charles A. Parkos, Jennifer Catherine Brazil

This study shows CD45 promotes PMN transepithelial migration, antimicrobial function, and colonic mucosal repair by regulating CD11b/CD18 and Lyn.

JCI Insight · Jun 23, 2026Peer-reviewedImmunology

RUNX2 promotes epigenetic WNT signaling in inflamed intestinal epithelial cells

Rodolfo Ismael Cabrera-Silva, Zachary Wilson, Jael Miranda, Shuling Fan, Michael K. Dame, Shrinivas Bishu, Jason R. Spence, Jennifer Catherine Brazil, Justin A. Colacino, Asma Nusrat, Charles A. Parkos

This study identifies RUNX2 as a regulator of WNT signaling in UC by analyzing snRNA-seq and snATAC-seq data from UC patient-derived colonoids.

bioRxiv · Nov 17, 2025 · PreprintPathology

Crb3 and NF2: A dynamic duo that controls assembly of the apical junctions and barrier function via Rho/ROCK signaling

Shuling Fan, Saranyaraajan Varadarajan, Vicky García‐Hernández, Ben L. Margolis, Charles A. Parkos, Asma Nusrat

This study shows Crb3 and NF2 regulate apical junctions and barrier function through Rho/ROCK signaling in intestinal epithelial cells.

bioRxiv · Jan 15, 2025 · PreprintCell Biology