Daniel J. Wallace

Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways

This study shows that loss of TRIM21 increases UVB-induced systemic inflammation by enhancing IFN expression through impaired STING signaling in mice.

Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

The paper identifies five SNPs in the DDX6-CXCR5 locus associated with autoimmune diseases and shows their functional effects on gene regulation in immune and epithelial cells.

Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE

The paper identifies gene signatures and pathways associated with coronary microvascular disease in SLE patients through RNA-seq and pathway analysis.