Author

Arati Naveen Kumar

Cedars-Sinai Medical CenterORCID 0000-0002-9877-5239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Caroline Anne JefferiesiD· 3 shared Daniel J. WallaceiD· 2 shared Gantsetseg TumurkhuuiD· 2 shared Lihong HuoiD· 2 shared MARIKO L. ISHIMORIiD· 2 shared Richard I. AinsworthiD· 2 shared Ahmed Gamal-Eldin IbrahimiD· 1 shared Aleksandr B. StotlandiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

Caroline Anne JefferiesORCID

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Author profile →

4 papers

Recent·Most cited

Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury

Ahmed Gamal-Eldin Ibrahim, Alessandra Ciullo, Hiroaki Komuro, Kazutaka Miyamoto, Xaviar Michael Jones, Shukuro Yamaguchi, Kara Tsi, Jessica Anderson, Joshua Godoy Coto, Diána Kitka, Ke Liao, Chang Li, Alice Rannou, Asma Nawaz, Ashley Anne Morris, , Eduardo Marbán

TY1, a synthetic ncRNA, upregulates TREX1 in macrophages to reduce scar size after myocardial infarction.

Science Translational Medicine · Dec 3, 2025Peer-reviewedMolecular Biology

Mitochondrial instability contributes to IFN-driven heart disease.

Arati Naveen Kumar, Amelia Meecham, Deepika Rai, Brennan Kandalaft, Trinitee Oliver, Aleksandr B. Stotland, Asli E. Atici, Magali Novas Rivas, Richard I. Ainsworth, Megan Laura McCain, Sarah J. Parker, Caroline Anne Jefferies

This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.

bioRxiv · Sep 15, 2025 · PreprintImmunology

Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways

Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Richard I. Ainsworth, TRINITEE R. OLIVER, Gabriela De Los Santos, David R. Gibb, Jessica Carrière, Jeong Min Yu, Rachel Abuav, Lindsy J. Forbess, Daniel J. Wallace, MARIKO L. ISHIMORI, , Caroline Anne Jefferies

This study shows that loss of TRIM21 increases UVB-induced systemic inflammation by enhancing IFN expression through impaired STING signaling in mice.

Arthritis & Rheumatology · Jun 17, 2025Peer-reviewedImmunology

Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE

Lihong Huo, Arati Naveen Kumar, Gantsetseg Tumurkhuu, Moumita Bose, Daniel S. Berman, Daniel J. Wallace, Janet Wei, MARIKO L. ISHIMORI, C. Noel Bairey Merz, Caroline Anne Jefferies

The paper identifies gene signatures and pathways associated with coronary microvascular disease in SLE patients through RNA-seq and pathway analysis.

Scientific Reports · Jan 19, 2025Peer-reviewedBioinformatics