Roberta Schellino

Cortical projection neurons exhibit early maturation defects and selective degeneration in a mouse model of spinal muscular atrophy

This study identifies early maturation defects and selective degeneration of cortical projection neurons in a mouse model of SMA, highlighting cortical pathology beyond lower motor neurons.

Volume Electron Microscopy of Cortical Organoids: Methods for Region Identification, Connectome Reconstruction, and Organelle Segmentation

This paper establishes a workflow for applying volume electron microscopy to human cortical organoids, enabling micro-connectomic reconstruction at nanometer resolution.

Targeting Neuromuscular Junction Regeneration is a Therapeutic Strategy in ALS

This study shows that targeting NMJ regeneration and CXCR4 can improve motor function and survival in ALS models.