Alessandro Vercelli

Cortical projection neurons exhibit early maturation defects and selective degeneration in a mouse model of spinal muscular atrophy

This study identifies early maturation defects and selective degeneration of cortical projection neurons in a mouse model of SMA, highlighting cortical pathology beyond lower motor neurons.

Volume Electron Microscopy of Cortical Organoids: Methods for Region Identification, Connectome Reconstruction, and Organelle Segmentation

This paper establishes a workflow for applying volume electron microscopy to human cortical organoids, enabling micro-connectomic reconstruction at nanometer resolution.

Challenges and promises in optimising a non-clinical protocol of intracerebroventricular human neural stem cell transplantation in ALS

This study evaluates the safety and efficacy of human neural stem cell transplantation in ALS using immunodeficient mice, finding it safe and showing potential therapeutic benefits with prolonged immunosuppression.