Nadine Rouphael

This paper identifies 23 candidate causal genes for critical COVID-19 by integrating severity-stratified, longitudinal cis-eQTL mapping with GWAS signals from 1,031 patients.

This study evaluates antibody responses after a KP.2 spike mRNA vaccine dose, showing durable and broadly cross-reactive immunity against multiple SARS-CoV-2 variants, but reduced neutralizing activity against some emerging subvariants.

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

This study identifies innate antiviral readiness as a key driver of TSCM cell expansion, showing its predictive value for viral clearance and vaccine design.

The paper identifies a multi-omics recovery factor predictive of long COVID using data from the IMPACC study, showing it can predict LC risk early after infection.

This study identifies immune subtypes in hospitalized COVID-19 patients linked to clinical outcomes and long COVID risk through longitudinal multi-omics analysis.

This study investigates viral reactivation in COVID-19 patients, finding associations between reactivation of specific virus families and clinical outcomes, including mortality and PASC symptoms.

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.

This study benchmarks RNA-Seq technical parameters in a clinical vaccine trial to establish guidelines for future studies.

The paper introduces the Immune Signatures Data Resource, a compendium of standardized systems vaccinology datasets for comparative vaccine response analysis.