Lucas M. Ferreri

Viral dispersal drives changes in population composition

The paper investigates how spatial expansion and dispersal modulators affect viral population structure and genetic diversity during infection.

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

Viral lineage and mode of exposure modulate within host spatial dynamics of influenza A viruses

This study shows that influenza A virus lineage and exposure route affect its spatial distribution and genetic diversity within the respiratory tract of guinea pigs.

Passage of human-origin influenza A virus in swine tracheal epithelial cells selects for adaptive mutations in the hemagglutinin gene

This study shows that serial passage of a human-origin H3N2 virus in swine tracheal epithelial cells selects for adaptive HA mutations that increase viral fitness in swine cells.

Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.