Author

Philipp Knyphausen

University of CambridgeORCID 0000-0002-2544-7920Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Organism:yeast· 2 Assay:proteomics· 1

Frequent Co-Authors

Florian HollfelderiD· 2 shared Katrin FischeriD· 1 shared Lutz JermutusiD· 1 shared Mariana Rangel Pereira· 1 shared Marko HyvöneniD· 1 shared Marta NapiorkowskaiD· 1 shared Matthew PenneriD· 1 shared P. BreariD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersSynthetic Biology

Florian HollfelderORCID

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2 papers

Recent·Most cited

YeastIT: Reducing mutational bias for in vivo directed evolution using a novel yeast mutator strain based on dual adenine-/cytosine-targeting and error-prone DNA repair

Marta Napiorkowska, Katrin Fischer, Matthew Penner, Philipp Knyphausen, Florian Hollfelder

YeastIT enables continuous in vivo protein evolution by reducing mutational bias and improving mutation rates compared to existing methods.

bioRxiv · Nov 20, 2023 · PreprintSynthetic Biology

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

Philipp Knyphausen, Mariana Rangel Pereira, P. Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder

This paper introduces a method to evolve protease activity and specificity using yeast display and alpha-2-macroglobulin-mediated covalent capture, demonstrating its application on six serine proteases.

Nature Communications · Feb 10, 2023Peer-reviewedSynthetic Biology