Katrin Fischer

YeastIT enables continuous in vivo protein evolution by reducing mutational bias and improving mutation rates compared to existing methods.

This study shows that Plakoglobin regulates naive pluripotency in mouse ESCs through mechanosensitivity, with expression specific to the blastocyst stage in human and mouse embryos.

The paper introduces DNA-based phenotypic recording to generate large-scale sequence-function datasets and uses deep learning to predict gene regulatory element function with high accuracy.