Alejandro Colman‐Lerner

The paper measures nuclear transport rates in single yeast cells using FRAP and identifies variability in nuclear pore complexes and other factors as sources of cell-to-cell differences.

The paper analyzes how gene expression can identify and assess extracellular stimuli encoded in transcription factor nuclear concentration amplitude, duration, or frequency, finding frequency modulation is most selective for stimulus identification.

The paper investigates how intrinsic polarization cues interfere with pheromone gradient sensing in S. cerevisiae, revealing three new features of the signaling system.

The paper analyzes how ligand-receptor systems, covalent modification cycles, and transcriptional networks behave before reaching steady-state, showing that they can operate in a PRESS mode.

The paper investigates how microtubule function affects cell-to-cell variability in the yeast pheromone response, showing that microtubules stabilize signaling and improve fate decision accuracy.

The paper identifies 50 genes that control cell-to-cell variability in the yeast pheromone response through a high-throughput screen.