Roger Brent

This study quantifies how dose-response relationships in signaling systems affect information transmission under various noise distributions and identifies design principles for improved signaling fidelity.

The paper shows that individual yeast cells signal consistently over time, indicating that their signaling pathways transmit information precisely.

The paper introduces Evolverator, a yeast system for continuous in vivo protein evolution, and demonstrates its use in improving ligand affinity and generating stronger repressors.

The paper describes a gene expression control system in yeast that suppresses variation and allows precise protein dosage regulation through autorepression and leaky expression prevention.

The paper introduces a genetic controller, WTC846, for precise, adjustable, and variation-free gene expression in yeast, enabling controlled phenotypic studies.

The paper identifies hsp-16.2 chaperone biomarkers as indicators of proteome dosage states in C. elegans, revealing cell-to-cell variation linked to gene expression differences.

The paper quantifies Intron Mediated Enhancement (IME) in C. elegans by measuring protein expression levels using fluorescent reporters and finds a single intron can increase expression by about 50%.

The paper investigates how microtubule function affects cell-to-cell variability in the yeast pheromone response, showing that microtubules stabilize signaling and improve fate decision accuracy.

The paper identifies 50 genes that control cell-to-cell variability in the yeast pheromone response through a high-throughput screen.