Dan Hasson

The paper develops ChromE-seq to study 3D chromatin architecture in fetal hematopoiesis, finding that T21 disrupts B-lineage development by altering chromatin connectivity and regulatory circuits.

This paper uses a CRISPR-based humanized model to show that STAG2 loss cooperates with GATA2 deficiency to drive MDS progression through increased HSC self-renewal and myeloid bias.

The paper identifies a tumor-promoting role of Nup93-2 in Drosophila, showing its specific effect on gene silencing and JAK/STAT signaling through Polycomb domains.

The paper identifies AP-1 family transcription factors as critical regulators of beta cell maturation by analyzing epigenomic and transcriptomic profiles of human insulinomas.

This study shows ATM regulates metabolic stress in SCLC by affecting ATF4 and MYC, leading to ferroptotic cell death and revealing a new therapeutic target.

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

The paper constructs a spatial transcriptomic atlas of human skin, identifying 45 cell types across 15 sites and revealing neighborhood disruptions in disease.

The paper shows that the PBAF complex in melanoma facilitates REST occupancy at repressive chromatin, leading to upregulation of synaptic transcripts when ARID2 is mutated.

The paper identifies a mechanism where TORC1-driven translation of Nup44A promotes chromatin remodeling and facilitates the germ cell-to-maternal transition in Drosophila.

The paper identifies a common flanking variant linked to increased meiotic stability at the FGF14-SCA27B repeat locus.

The paper shows that genome organization influences NPC formation and differentiation in Drosophila oogenesis by regulating gene silencing and Nup activation.

This study identifies ZNF gene 3 exons as novel ATRX target regions, showing ATRX maintains H3K9me3 enrichment to preserve genomic stability.