Jun Yang

This study demonstrates that molecularly produced light from ADLumin-5 can degrade misfolded proteins like beta-amyloid and reduce their toxicity in vitro and in vivo.

This paper introduces a chemiluminescence probe, ADLumin-1, that enables both generic and precise detection of misfolded proteins in neurodegenerative disease models.

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.