NeuroscienceScience Translational MedicinePeer-reviewed
Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction
Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai…·Aaron D. Gitler
This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.
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