This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.

Science Translational Medicine · Jun 3, 2026Peer-reviewedNeuroscience

Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture

Maria Kowald, Sylvestre P. J. T. Bachollet, Fritz Benseler, Maria Steinecker, Moritz Boll, Sofia Kaushik, Tolga Soykan, Siqi Sun, Ramona Birke, Dragana Ilic, Nils Brose, Hanna Hörnberg, Martin Lehmann, Silvio O. Rizzoli, Johannes Broichhagen, Noa Lipstein

This paper introduces a knock-in mouse line with endogenous Munc13-1-SNAP for monitoring presynaptic nanoarchitecture using SNAP-tag labeling and live-cell imaging.

JACS Au · May 23, 2025Peer-reviewedNeuroscience

Multi-level monitoring of EME1-MUS81 in CPT induced nucleolar rDNA repair

Bakshi Karishma, Easa Nagamalleswari, Jan Breucker, Nathalie Eisenhardt, Richa Tiwari, Román González‐Prieto, Chronis Fatouros, Viduth K. Chaugule, Heekyoung Lee, Dragana Ilic, Fredrik Trulsson, Gerhard Mittler, Alfred C.O. Vertegaal, Andrea Pichler

The paper investigates how sumoylation modifications regulate EME1-MUS81 functions in CPT-induced rDNA repair by analyzing variants and interactomes.

bioRxiv · Apr 11, 2022 · PreprintMolecular Biology