Author

Mollie A. Brekker

Boston UniversityORCID 0000-0002-2603-1089Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Assen MarintcheviD· 2 shared Autumn O Grimins· 2 shared Mohsan SaeediD· 2 shared Ryan Johnston· 2 shared Sami Gritli· 2 shared Shawn M. LyonsiD· 2 shared Alan WacquieziD· 1 shared Anne Aldrich· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Assen MarintchevORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

eIF4E3 drives translation of viral mRNAs with short 5' UTRs

Autumn O Grimins, Mollie A. Brekker, Sarah Ruth Shick, Ellen L. Suder, Victoria A. Kleiner, Sami Gritli, Ryan Johnston, Alan Wacquiez, Mohsan Saeed, Assen Marintchev, Elke Mühlberger, Rachel Fearns, John H. Connor, Shawn M. Lyons

The paper shows eIF4E3 enables efficient translation of viral mRNAs with short 5' UTRs, unlike the canonical eIF4E1, and identifies this as a mechanism used by viruses like VSV to bypass host translation suppression.

bioRxiv · May 26, 2026 · PreprintMolecular Biology

Proteolytic dissection of eIF4G reveals the closed-loop mRNP as an architecture for translation repression.

Ryan Johnston, Mollie A. Brekker, Noelle Khalil, Monty E. Goldstein, Anne Aldrich, Autumn O Grimins, Sami Gritli, Assen Marintchev, Michael D. Blower, Mohsan Saeed, Shawn M. Lyons

The paper shows that eIF4G cleavage products can either rescue or repress translation, revealing the closed-loop mRNP's role in translational silencing rather than initiation.

bioRxiv · Apr 7, 2026 · PreprintMolecular Biology