Assen Marintchev

NMR assignments and secondary structure analysis of the human 5MP1 C-terminal domain

This study provides NMR resonance assignments and secondary structure analysis of the human 5MP1 C-terminal domain, revealing structural discrepancies between experimental data and AlphaFold predictions.

eIF4E3 drives translation of viral mRNAs with short 5' UTRs

The paper shows eIF4E3 enables efficient translation of viral mRNAs with short 5' UTRs, unlike the canonical eIF4E1, and identifies this as a mechanism used by viruses like VSV to bypass host translation suppression.

Proteolytic dissection of eIF4G reveals the closed-loop mRNP as an architecture for translation repression.

The paper shows that eIF4G cleavage products can either rescue or repress translation, revealing the closed-loop mRNP's role in translational silencing rather than initiation.

NMR assignments and secondary structure analysis of the eIF1-interacting fragment of human eIF3c

This paper reports NMR assignments and secondary structure analysis of an intrinsically disordered fragment of human eIF3c, showing it is disordered with transient structural elements.

Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2

This study investigates the molecular interactions of eIF2β with eIF5, eIF2B, and 5MP1 using crystallography and NMR, revealing binding sites and regulatory roles of CK2 phosphorylation.

The PCI domains are "winged" HEAT domains

The paper shows PCI domains are structurally more similar to certain HEAT domains than to other HEAT domains, suggesting PCI domains evolved from a HEAT domain with a WH subdomain.