Proteolytic dissection of eIF4G reveals the closed-loop mRNP as an architecture for translation repression.
Ryan Johnston, Mollie A. Brekker, Noelle Khalil, Monty E. Goldstein, Anne Aldrich, Autumn O Grimins, Sami Gritli, Assen Marintchev, Michael D. Blower, Mohsan Saeed, Shawn M. Lyons
The paper shows that eIF4G cleavage products can either rescue or repress translation, revealing the closed-loop mRNP's role in translational silencing rather than initiation.
bioRxiv · Apr 7, 2026 · PreprintMolecular Biology