Author

Ryan Johnston

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Shawn M. LyonsiD· 3 shared Assen MarintcheviD· 2 shared Autumn O Grimins· 2 shared Michael D. BloweriD· 2 shared Mohsan SaeediD· 2 shared Mollie A. BrekkeriD· 2 shared Sami Gritli· 2 shared Alan WacquieziD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMolecular Biology

Shawn M. LyonsORCID

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Author profile →

3 papers

Recent·Most cited

eIF4E3 drives translation of viral mRNAs with short 5' UTRs

Autumn O Grimins, Mollie A. Brekker, Sarah Ruth Shick, Ellen L. Suder, Victoria A. Kleiner, Sami Gritli, Ryan Johnston, Alan Wacquiez, Mohsan Saeed, Assen Marintchev, Elke Mühlberger, Rachel Fearns, John H. Connor, Shawn M. Lyons

The paper shows eIF4E3 enables efficient translation of viral mRNAs with short 5' UTRs, unlike the canonical eIF4E1, and identifies this as a mechanism used by viruses like VSV to bypass host translation suppression.

bioRxiv · May 26, 2026 · PreprintMolecular Biology

Proteolytic dissection of eIF4G reveals the closed-loop mRNP as an architecture for translation repression.

Ryan Johnston, Mollie A. Brekker, Noelle Khalil, Monty E. Goldstein, Anne Aldrich, Autumn O Grimins, Sami Gritli, Assen Marintchev, Michael D. Blower, Mohsan Saeed, Shawn M. Lyons

The paper shows that eIF4G cleavage products can either rescue or repress translation, revealing the closed-loop mRNP's role in translational silencing rather than initiation.

bioRxiv · Apr 7, 2026 · PreprintMolecular Biology

Decreased tRNA abundance contributes to decreased translation elongation rate in a prolonged mitosis

Emily Sparago, Ryan Johnston, Shawn M. Lyons, Michael D. Blower

The paper shows that decreased tRNA abundance reduces translation elongation during mitosis, leading to reduced protein synthesis.

bioRxiv · Jan 14, 2026 · PreprintCell Biology