Joerg Betschinger

This study identifies ZBTB2 as a btb-domain transcription factor that recruits chromatin remodelers and a histone chaperone during exit from pluripotency, revealing shared and unique functions of the btb-TF family.

This study identifies Hdac3 and Dax1 as repressors that restrict mESCs from transdifferentiating into extraembryonic endoderm by silencing Gata6 enhancers, while Nr5a2 and Esrrb promote this conversion.