Yumiko Kawamura

The paper introduces HisTrac-seq to track cell identity transitions over time using single-cell multi-omics, revealing large-scale 'identity jumps' in mouse brain cells.

This study shows that KDM2A and KDM2B prevent aberrant DNA methylation in mouse oocytes, which is critical for early embryonic development.

This study identifies H3K27me3's role in regulating genome-nuclear lamina interactions and allelic asymmetry during early mouse embryogenesis through single-cell LAD profiling and chromatin state analysis.

This study identifies Hdac3 and Dax1 as repressors that restrict mESCs from transdifferentiating into extraembryonic endoderm by silencing Gata6 enhancers, while Nr5a2 and Esrrb promote this conversion.

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

This paper develops a method for high fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins and light-sheet imaging.

The paper investigates the role of Dlx5/6 in cranial neural crest cells in determining jaw identity and symmetry, showing that their expression in NCCs is critical for lower jaw development and jaw matching.