Marc Dhénain

Normal aging increases white matter microglial reaction and perivascular macrophages in the microcebe primate

This study examines age-related changes in microglia and perivascular macrophages in microcebe primates, finding increased HLA-DR+ expression in white matter and perivascular regions with aging.

Astrocyte diversity and aging in the mouse lemur primate brain

This study characterizes astrocyte diversity and age-related changes in the mouse lemur brain, identifying region-specific vulnerabilities and distinct astrocyte subtypes.

APPNL-F knock-in Alzheimer's Disease model mice reveal etiological convergence of aging and amyloidosis

This study characterizes the early stages of amyloidosis and neuroinflammation in APPNL-F AD model mice, revealing a link between microglial senescence and disease progression.

Mean amplitude of low frequency fluctuations measured by fMRI at 11.7T in the aging brain of mouse lemur primate

The paper measures mean amplitude of low-frequency fluctuations (mALFF) in mouse lemurs to identify age-related changes in cerebral function using fMRI.

Whole brain mapping of glutamate in adult and old primates at 11.7T

The paper maps glutamate distribution in adult and old primate brains using high-field gluCEST imaging, identifying age-related changes in specific brain regions and networks.

Identification of the key role of white matter alteration in the pathogenesis of Huntington's Disease

This study uses longitudinal MRI in a mouse model to show early white matter defects in Huntington's Disease, highlighting their role in pathogenesis and identifying potential biomarkers.

Pathological changes induced by Alzheimer's brain inoculation in amyloid-beta plaque bearing mice

This study shows that injecting human Alzheimer's brain extracts into mice with amyloid-beta plaques induces tau pathology, memory deficits, and synaptic loss, with neuritic plaques linked to synaptic impairment.

Resting state cerebral networks in mouse lemur primates: from multilevel validation to comparison with humans

The paper identifies and compares resting-state brain networks in mouse lemurs and humans using functional MRI and multiple analytical methods.

An Automated Open-Source Workflow for Standards-Compliant Integration of Small Animal Magnetic Resonance Imaging Data

The paper presents an open-source workflow to convert small animal MRI data from ParaVision to BIDS format, improving data standardization and compatibility.

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

This study identifies reproducible resting-state networks in the mouse brain across multiple centers using standardized rsfMRI analysis.