Yacine Kherdjemil

Induction of cellular totipotency by NACC1-driven feed-forward regulation.

The paper identifies NACC1 as a regulator of totipotent-like cells in mouse embryonic stem cells through a feed-forward mechanism involving gene regulation and retrotransposon activity.

SPT5 regulates Pol II pausing and elongation in different ways at early versus late embryonic stages

This study shows SPT5 regulates Pol II pausing and elongation differently in early and late Drosophila embryogenesis, affecting gene expression dynamics.

Chip (Ldb1) is a new cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation

The paper shows that Ldb1 (Chip) is a cofactor of Zelda that bridges to CBP to regulate gene expression during zygotic genome activation in Drosophila.

Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways

The paper maps the interactome of ARF and ARL proteins using BioID, identifies new localizations, and reveals functional roles of ARL14 in activating PLD1 and cargo trafficking.

HOX13-dependent chromatin accessibility modulates the target repertoires of the HOX factors

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.