Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice
Oswaldo A. Lozoya, Fu‐Hua Xu, Dagoberto Grenet, Tianyuan Wang, Korey D. Stevanovic, Jesse D. Cushman, Patricia Jensen, Bairon Hernández, Gonzalo Riadi, Sheryl S. Moy, Janine Hertzog Santos, Richard P. Woychik
This study shows that a brain-specific PGC1α isoform mutation causes motor deficits and gene upregulation in female mice, suggesting a role in female-specific transcriptional programs.
bioRxiv · Sep 18, 2020 · PreprintNeuroscience