Author

Dagoberto Grenet

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Janine Hertzog SantosiD· 3 shared Oswaldo A. LozoyaiD· 3 shared Richard P. WoychikiD· 3 shared Tianyuan WangiD· 3 shared Gonzalo RiadiiD· 2 shared Bairon HernándeziD· 1 shared Douglas Ganini da Silva· 1 shared Fu‐Hua XuiD· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Janine Hertzog SantosORCID

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3 papers

Recent·Most cited

Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice

Oswaldo A. Lozoya, Fu‐Hua Xu, Dagoberto Grenet, Tianyuan Wang, Korey D. Stevanovic, Jesse D. Cushman, Patricia Jensen, Bairon Hernández, Gonzalo Riadi, Sheryl S. Moy, Janine Hertzog Santos, Richard P. Woychik

This study shows that a brain-specific PGC1α isoform mutation causes motor deficits and gene upregulation in female mice, suggesting a role in female-specific transcriptional programs.

bioRxiv · Sep 18, 2020 · PreprintNeuroscience

Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

Oswaldo A. Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Sara A. Grimm, Veronica Godfrey, Suramya Waidyanatha A, Richard P. Woychik, Janine Hertzog Santos

This study shows that maternal exposure to rotenone alters DNA methylation and gene expression in offspring, with long-term effects on health and disease.

Cell Reports · Sep 1, 2020Peer-reviewedGenomics

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

Oswaldo A. Lozoya, Tianyuan Wang, Dagoberto Grenet, Taylor C. Wolfgang, Mack Sobhany, Douglas Ganini da Silva, Gonzalo Riadi, Navdeep S. Chandel, Richard P. Woychik, Janine Hertzog Santos

This study shows that mitochondrial acetyl-CoA reversibly modulates histone acetylation and gene expression in models of mtDNA depletion.

Life Science Alliance · Feb 1, 2019Peer-reviewedGenomics