Zhao V. Wang

Role of Uridine Phosphorylase 1 (UPP1) in Pancreatic β-Cell Physiology and Its Dysregulation in Obesity and Type 2 Diabetes

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

Androgen receptor contributes to radioresistance through DNA repair and autophagy in AR-positive prostate cancer cells

This study shows that androgen receptor promotes radioresistance in prostate cancer by enhancing DNA repair and autophagy.

De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis

This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.

Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex

This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.

Multi-omic Profiling of Senescence Following Myocardial Infarction Reveals Dynamic Characteristics in Cardiac Remodeling

This study uses multi-omic profiling to show that senescent cells, particularly late myofibroblasts, transiently contribute to cardiac remodeling after myocardial infarction.