Craig A. Smibert

Pumilio and Brain tumor regulate the expression of Smaug during the Drosophila maternal-to-zygotic transition

This study shows that Pumilio and Brain tumor regulate Smaug mRNA degradation during the Drosophila maternal-to-zygotic transition, preventing ectopic Smaug protein expression and ensuring proper mRNA clearance.

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

Ataxin-2 regulates the synaptonemal complex to ensure chromosome pairing during female meiosis

This study identifies Ataxin-2 as a regulator of the synaptonemal complex in Drosophila, showing its role in chromosome pairing during meiosis.

The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc binding 'ZZ' domain

This study identifies ORB2 as a regulator of maternal mRNAs during the Drosophila MZT, showing its ZZ domain mediates repression through interactions with post-transcriptional regulators.

Post-transcriptional regulatory pre-complex assembly drives timely cell-state transitions during differentiation

The paper identifies Usp5 as a key interactor of Brat that facilitates pre-complex assembly for mRNA degradation during differentiation in Drosophila.

Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing the oskar and bruno 1 mRNAs

The paper identifies Smaug's role in repressing osk and bru1 mRNAs to regulate germ plasm synthesis and PGC number in Drosophila embryos.

Regulation of the Drosophila transcriptome by Pumilio and CCR4-NOT deadenylase

This study identifies novel Pumilio target genes and reveals how Pumilio and CCR4-NOT deadenylase regulate mRNA stability and translation efficiency in Drosophila.

BrainRBPedia: a resource for RNA-binding proteins relevant to neurodevelopmental disorders

BrainRBPedia is a database of 1072 RNA-binding proteins linked to neurodevelopmental disorders, with a machine learning model prioritizing RBPs for autism and intellectual disability.

Precise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition

The paper shows that precise degradation of post-transcriptional repressors during the Drosophila MZT is essential for orderly transition to zygotic gene control.

The RNA-binding protein, Rasputin/G3BP, enhances the stability and translation of its target mRNAs

This study identifies RIN/G3BP-bound mRNAs in Drosophila and shows they are short, stable, and highly translated, suggesting RIN stabilizes and enhances their translation.

RanBP2/Nup358 enhances miRNA activity by sumoylating and stabilizing Argonaute 1

This study shows RanBP2/Nup358 enhances miRNA activity by sumoylating and stabilizing Argonaute 1, which represses IL6 mRNA translation in ANE1.