This study shows that daily intermittent fasting reduces seizure frequency and improves sociability in mouse models of absence epilepsy without adverse effects.

Epilepsia · Nov 15, 2025Peer-reviewedNeuroscience

Spatio-temporal X-linked gene reactivation and site-specific retention of epigenetic silencing in the in vivo germline.

Clara Roidor, Laurène Syx, Emmanuelle Beyne, Peggy Raynaud, Dina Zielinski, Aurélie Teissandier, Caroline Lee, Marius Walter, Nicolas Servant, Karim Chébli, Déborah Bourc’his, M. Azim Surani, Maud Borensztein

The paper maps X-linked gene reactivation and epigenetic silencing in developing PGCs, showing partial resistance to reactivation and enrichment of repressive marks.

Nature Structural & Molecular Biology · Jan 21, 2025Peer-reviewedDevelopmental Biology

Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Kader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Ida Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Déjardin, Sylvie Rouquier, Olivier Cuvier, Rosemary E. Kiernan

The paper identifies the MRN complex's role in protecting actively transcribing genes from genomic instability through transcriptional association.

Science Advances · May 21, 2021Peer-reviewedMolecular Biology