Kelly Perlman

This study characterizes the lipid composition of the human uncinate fasciculus and finds age-related changes but no significant differences related to depression or childhood abuse.

This study characterizes the human uncinate fasciculus using multimodal approaches, finding no group differences in histology but identifying differentially expressed genes and age-related changes.

The paper develops and validates a novel sf-CARS system with AxonDeepSeg to analyze UF ultrastructure in human postmortem brain tissue, finding mean axon diameter and myelin thickness.

The paper validates the presence of neuronal cell bodies in human long-range white matter tracts, finding higher densities in the uncinate fasciculus compared to other regions.

This study develops a method to isolate oligodendrocyte-lineage cells from postmortem brain tissue and finds age-related gene expression changes and a correlation between oligodendrocyte density and myelin area in the basolateral amygdala.

This study identifies proteomic changes in the human male olfactory bulb associated with depression, highlighting astrocytic dysfunction and species-specific differences in mouse models.

This study shows that child abuse is linked to increased perineuronal net recruitment in the ventromedial prefrontal cortex, potentially through oligodendrocyte progenitor cell activity.

This study compares fatty acid concentrations in the anterior cingulate cortex of depressed suicides with and without a history of child abuse, finding age-related decreases and specific effects of child abuse on arachidonic acid synthesis pathway FAs.

The paper uses single-nucleus RNA sequencing to identify gene expression changes in specific cell types associated with major depressive disorder.

The paper uses deep learning to predict differential treatment benefits for depression using STAR*D and CO-MED data, showing improved remission rates with model-guided treatment selection.