Maria Antonietta Davoli

The paper identifies spatially localized astrocytic dysfunction in depression using multi-omics data and shows its role in disease pathology.

This study characterizes the human uncinate fasciculus using multimodal approaches, finding no group differences in histology but identifying differentially expressed genes and age-related changes.

The paper shows that serotonergic neurons in the dorsal raphe nucleus adjust oxygen utilization in response to traumatic stress, with distinct patterns linked to susceptibility or resilience.

This study identifies widespread gene expression changes in the neurovascular unit of female depressed suicides with childhood abuse histories, highlighting key regulators like KLF2 and KLF4.

The paper develops and validates a novel sf-CARS system with AxonDeepSeg to analyze UF ultrastructure in human postmortem brain tissue, finding mean axon diameter and myelin thickness.

The paper validates the presence of neuronal cell bodies in human long-range white matter tracts, finding higher densities in the uncinate fasciculus compared to other regions.

This study identifies differential chromatin architecture and risk variants in specific brain cell types associated with major depressive disorder.

This study develops a method to isolate oligodendrocyte-lineage cells from postmortem brain tissue and finds age-related gene expression changes and a correlation between oligodendrocyte density and myelin area in the basolateral amygdala.

The paper investigates how childhood abuse affects the locus coeruleus-noradrenergic system in post-mortem brain samples, finding reduced neuron density and differential gene expression in resilient individuals.

The paper investigates how childhood abuse affects microglial markers and perineuronal nets in the ventromedial prefrontal cortex of individuals who died by suicide.

The paper uses spatial transcriptomics and FISH to analyze adult hippocampal neurogenesis in the human dentate gyrus across ages, finding few neural stem cell markers but significant DCX expression with mixed inhibitory and excitatory phenotypes.

This study identifies proteomic changes in the human male olfactory bulb associated with depression, highlighting astrocytic dysfunction and species-specific differences in mouse models.

The paper compares cerebellar astrocytes and Purkinje cells across humans, macaques, and mice, finding species-specific differences in distribution, size, and marker expression.

This study examines CS disaccharide sulfation patterns in human and mouse brains, finding regional and species-specific differences and showing ELS does not affect PNN labeling patterns.

The paper introduces a method to isolate intact microvessels from frozen tissue and uses multi-omics to characterize the neurovascular unit.

This study shows that child abuse is linked to increased perineuronal net recruitment in the ventromedial prefrontal cortex, potentially through oligodendrocyte progenitor cell activity.

The paper investigates changes in vimentin-immunoreactive astrocytes and blood vessels in depressed suicides compared to controls, finding reduced astrocyte density but no significant vascular changes.

The paper uses single-nucleus RNA sequencing to identify gene expression changes in specific cell types associated with major depressive disorder.