Author

Grzegorz Sienski

AstraZeneca (Sweden)ORCID 0000-0002-2730-7710Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Marcello MarescaiD· 2 shared Martin PeterkaiD· 2 shared Nina Akrap· 2 shared Pei-Pei Hsieh· 2 shared Anders Dahlen· 1 shared Anders LundiniD· 1 shared Angela Membrino· 1 shared Anna Baran· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMolecular Biology

Marcello MarescaORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 9, 2026

Artemis Regulates Homology-Independent Prime Editing (PRINS) for Enhanced Genomic Insertions

Louis C. Dacquay, Oi Kuan Choong, Angela Membrino…·Marcello Maresca

This study identifies Artemis as a regulator of PRINS editing, showing that modulating Artemis improves insertion efficiency and specificity for genomic engineering.

DOI 10.64898/2025.12.08.693005

humanCRISPR screen

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedMar 24, 2022

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Martin Peterka, Nina Akrap, Songyuan Li…·Marcello Maresca

This paper develops two prime editing strategies using DSB repair to improve genomic insertion efficiency and purity, expanding the prime editing toolkit.

54 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 27, 2021

A SUMO-dependent regulatory switch connects the piRNA pathway to the heterochromatin machinery in Drosophila

Veselin I. Andreev, Changwei Yu, Juncheng Wang…·Julius Brennecke

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

DOI 10.1101/2021.07.27.453956

Drosophilastatistical model

𝕏 PostBluesky