Changwei Yu

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing

The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.

The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters

This study identifies Kipferl as a cofactor that recruits Rhino to piRNA clusters by binding DNA motifs and interacting with Rhino's chromodomain, revealing DNA sequence as a determinant of piRNA source loci.

A SUMO-dependent regulatory switch connects the piRNA pathway to the heterochromatin machinery in Drosophila

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

TBPL2/TFIIA complex establishes the maternal transcriptome by an oocyte-specific promoter usage

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.

Global regulatory transitions at core promoters demarcate the mammalian germline cycle

The paper identifies global regulatory transitions at core promoters during mammalian germline development, showing a shift from somatic to maternal promoter codes in oogenesis.