Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization
Jeswin Joseph, Lingshu Wang, Sheena Vasquez, Chia-Ming Su, Daniel Wrapp, Osnat Rosen, Olubukola M. Abiona, Christian K. O. Dzuvor, Robert N. Kirchdoerfer, Sydney P. Moak, Timothy Patrick Sheahan, Catherine Hammond, Wei Shi, Wing‐Pui Kong, Yi Zhang, , Kizzmekia S. Corbett
This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.
bioRxiv · Oct 29, 2025 · PreprintMicrobiology