Étienne Herzog

Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses

The paper uses cryo-correlative light and electron tomography to study dopamine and glutamatergic synaptosomes in the striatum of adult mice, revealing differences in vesicle organization and release readiness between the two types.

A minor impact of VGLUT1 expression level on quantal size revealed through the characterization of VGLUT1mEos2 knock-down new mouse model

The paper characterizes a VGLUT1 knock-down mouse model and finds that reduced VGLUT1 expression does not significantly affect quantal size or frequency of glutamate release.

Synaptomic analysis of dopaminergic inputs reveal hub synapses in the mouse striatum.

The paper identifies hub synapses in the mouse striatum formed by dopaminergic inputs that connect with glutamatergic, GABAergic, and cholinergic synapses, revealing a new framework for studying neuromodulation.

Subcellular and regional localization of mRNA translation in midbrain dopamine neurons

The paper investigates mRNA localization and translation in midbrain dopaminergic neurons, finding no axonal localization but dendritic ribosomes and mRNAs related to dopamine synthesis and release.

Mammalian vesicular glutamate transporter VGLUT1 reduces synaptic vesicle superpool size and spontaneous release frequency.

The paper identifies a mechanism by which VGLUT1 increases synaptic vesicle clustering, reducing superpool size and spontaneous release frequency through interactions with endophilinA1 and intersectin1.

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments.

The paper demonstrates that local protein synthesis occurs in both pre- and postsynaptic compartments of neurons, including excitatory and inhibitory axon terminals.