Author

Sohani Das Sharma

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:Ribo-seq· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Jordan B. MetziD· 3 shared Peter A. SimsiD· 3 shared Nicholas J. HornsteiniD· 2 shared Aayushi MahajaniD· 1 shared Aida Razavilar· 1 shared Alexander R. GoldbergiD· 1 shared Angeliki MelaiD· 1 shared Ankita Saxena· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Jordan B. MetzORCID

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Author profile →

3 papers

Recent·Most cited

Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition

Alexander R. Goldberg, Athanassios Dovas, Daniela Torres, Brianna Pereira, Ashwin Viswanathan, Sohani Das Sharma, Angeliki Mela, Edward M. Merricks, Cristina Megino‐Luque, Julie J. McInvale, Markel Olabarria, Leila Abrishami Shokooh, Hanzhi Zhao, Cady Chen, Corina P. Kotidis, , Peter Canoll

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

Neuron · Mar 1, 2025Peer-reviewedNeuroscience

High-Throughput Translational Profiling with riboPLATE-seq

Jordan B. Metz, Nicholas J. Hornstein, Sohani Das Sharma, Jeremy Worley, Christian Gonzalez, Peter A. Sims

This study introduces riboPLATE-seq, a method for generating paired libraries of ribosome-associated and total mRNA, and demonstrates its use in detecting translational changes caused by kinase inhibitors.

Scientific Reports · Apr 5, 2022Peer-reviewedSystems Biology

Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knock-Out Mice

Sohani Das Sharma, Jordan B. Metz, Hongyu Li, Benjamin D. Hobson, Nicholas J. Hornstein, David L. Sulzer, Guomei Tang, Peter A. Sims

This study uses ribosome profiling to show that Fmr1 loss in mice affects translation elongation and initiation, with reduced pausing and altered mRNA binding.

Cell Reports · Mar 1, 2019Peer-reviewedMolecular Biology