Theresa E. Hickey

This study identifies AP-2β as a key regulator of active enhancers in molecular apocrine breast cancer, linking its expression to cell identity and proliferation.

This study identifies JNK pathway suppression as a driver of resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer, with implications for patient stratification.

This study investigates how androgen stimulation reorganizes 3D genome and epigenome states in prostate cancer cells to activate AR-mediated transcription.

This study shows that library size in spatial transcriptomics data confounds biological signals and recommends against normalizing it unless necessary.

This study shows that Decitabine suppresses tumour growth in ER+ breast cancer by inducing DNA hypomethylation and altering 3D chromatin structure.

This study investigates the molecular effects of androgen in the human breast using single-cell transcriptome, chromatin, and spatial profiling of transgender men undergoing androgen therapy, revealing changes in gene expression, immune populations, vasculature, and metabolism.