Author

Cara-lin Lonetree

University of MinnesotaORCID 0000-0002-2760-8572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Beau R. WebberiD· 2 shared Branden S. MoriarityiD· 2 shared Miechaleen D. Diers· 2 shared Mitchell G. KluesneriD· 2 shared Nicholas J. SlipekiD· 2 shared Walker S. LahriD· 2 shared Alexandria K. Gilkey· 1 shared Amber N. McElroyiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioengineering

Beau R. WebberORCID

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2 papers

Recent·Most cited

BioengineeringMolecular TherapyPeer-reviewedJul 18, 2026

A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells

Joseph G. Skeate, Nicholas J. Slipek, Walker S. Lahr…·Beau R. Webber

This paper develops a base editing platform to efficiently and safely engineer CAR T cells with multiple gene knockouts and insertions.

3 citations

humanCRISPR screen

𝕏 PostBluesky

GeneticsNature CommunicationsPeer-reviewedNov 19, 2019

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Beau R. Webber, Cara-lin Lonetree, Mitchell G. Kluesner…·Branden S. Moriarity

This study develops a method to efficiently edit multiple genes in human T cells using base editors, reducing off-target effects and improving safety for immunotherapy.

232 citationstop 1%

humanexperimental assay

𝕏 PostBluesky