Michael Shapiro

This study identifies DANCR as a conserved lncRNA essential for zebrafish development and a human melanoma oncogene, showing its role in regulating gene expression and promoting cancer progression.

The paper introduces TrajectoryGeometry to analyze cell fate decisions, finding that developmental pathways branch rather than bifurcate, with only cells taking the second branch making a decision.

The paper maps the regulatory landscape of neuronal and glial differentiation in the enteric nervous system using single-cell RNA sequencing and identifies gene modules and epigenetic memory associated with neurogenesis and gliogenesis.

The paper identifies Wnt-responsive cis-regulatory elements that coordinate Paupar-Pax6 expression in neuronal cells through chromatin interactions.