Author

Akishi Onishi

RIKENORCID 0000-0002-2775-6567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Organism:non-human primate· 1 Organism:rat· 1

Frequent Co-Authors

Junki Sho· 3 shared Masayo TakahashiiD· 3 shared Michiko MandaiiD· 3 shared Aiko Ishimaru· 2 shared Kazushi Yasuda· 2 shared Yoko Ohigashi· 2 shared Akiko Maeda· 1 shared Atsuta OzakiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersGenetics

Junki Sho

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mutation-agnostic gene insertion therapy for RHO-associated autosomal dominant retinitis pigmentosa using zinc finger nucleases

Akishi Onishi, Tetsushi Sakuma, Michiko Mandai, Takashi Watanabe, Takaho A. Endo, Wataru Nomura, Aiko Ishimaru, Kenichi Inoue, Junki Sho, Yoko Ohigashi, Yuki Nakano, Kazushi Yasuda, Atsuta Ozaki, Akiko Maeda, Chikako Morinaga, , Masayo Takahashi

This paper develops a mutation-agnostic gene insertion therapy for RHO-adRP using ZF-ND1-mediated HITI and validates its efficacy and safety in preclinical models.

bioRxiv · Jul 17, 2026 · PreprintGenetics

Efficient workflow for validating homology-independent targeted integration-mediated gene insertion in rod photoreceptor cells to treat dominant-negative mutations causing retinitis pigmentosa

Akishi Onishi, Yuji Tsunekawa, Michiko Mandai, Aiko Ishimaru, Yoko Ohigashi, Junki Sho, Kazushi Yasuda, Keiichiro Suzuki, Juan Carlos Izpisúa Belmonte, Fumio Matsuzaki, Masayo Takahashi

bioRxiv · Nov 8, 2023 · PreprintMolecular Biology

Genetically engineered retina for improved retinal reconstruction after transplantation

Take Matsuyama, Hung‐Ya Tu, Jianan Sun, Tomoyo Hashiguchi, Ryutaro Akiba, Junki Sho, Momo Fujii, Akishi Onishi, Masayo Takahashi, Michiko Mandai

This study shows genetically engineered retinal sheets improve visual recovery by enhancing neural integration and reducing aberrant activity after transplantation in mice.

iScience · Jul 16, 2021Peer-reviewedNeuroscience