Michiko Mandai

This paper develops a mutation-agnostic gene insertion therapy for RHO-adRP using ZF-ND1-mediated HITI and validates its efficacy and safety in preclinical models.

This study shows that Plagl2 reprograms adult mouse Müller glia into a progenitor-like state with both proliferative and neurogenic capabilities, enhancing retinal regeneration.

The paper investigates retinal spheroid layer formation by analyzing Rax::GFP-positive retinal progenitor cells, revealing sequential WNT signaling and environmental factors in retinal development.

This paper uses Hidden Markov Models to analyze mouse behavior in response to visual depth cues, revealing three behavioral states and insights into depth perception mechanisms.

This study transplants genome-edited retinal organoids into a primate macular degeneration model, showing host bipolar cells rewire and form functional synapses with grafted photoreceptors.

The paper develops a quality control method and preclinical studies for human iPSC-derived retinal sheets for transplantation therapy, showing safety and functional integration in rat models.

This study shows genetically engineered retinal sheets improve visual recovery by enhancing neural integration and reducing aberrant activity after transplantation in mice.

The paper analyzes single-cell RNA-Seq and ATAC-Seq data from native and iPSC-derived murine retina to identify regulatory toggles involved in differentiation.