Gábor Pápai

Specific binding modes of SIRT6 C-terminal domain to the nucleosome core particle influence DNA unwrapping and H3K27 accessibility

This study uses molecular dynamics simulations to investigate how the C-terminal domain of SIRT6 interacts with the nucleosome, influencing DNA unwrapping and H3K27 accessibility.

Novel insights into the structure and evolution of the human SAGA complex by affinity-ligand purification

This study reports the high-resolution structure of the human SAGA complex, revealing how the SPL module and TAF6L/HEAT repeats are integrated into the complex and their functional implications.

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

This study reveals how SIRT6 binds to nucleosomes to position its active site for efficient histone H3 deacetylation.

The CryoEM Structure of the Ribosome Maturation Factor Rea1

This paper presents three cryoEM structures of the Rea1 ribosome maturation factor, revealing its architecture and mechanism of action.