Author

Adam Ben Shem

Centre National de la Recherche ScientifiqueORCID 0000-0003-0297-8662Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Gábor PápaiiD· 3 shared Emmanuelle BignoniD· 2 shared Patrick SchultziD· 2 shared Ekaterina SmirnovaiD· 1 shared Làszlò ToraiD· 1 shared Luc LebeauiD· 1 shared Mylène DamilotiD· 1 shared Thomas Schoeps· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

Gábor PápaiORCID

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3 papers

Recent·Most cited

BiochemistryThe Journal of Physical Chemistry BPeer-reviewedSep 24, 2025

Specific binding modes of SIRT6 C-terminal domain to the nucleosome core particle influence DNA unwrapping and H3K27 accessibility

Yuya Qiu, Gábor Pápai, Adam Ben Shem, Emmanuelle Bignon

This study uses molecular dynamics simulations to investigate how the C-terminal domain of SIRT6 interacts with the nucleosome, influencing DNA unwrapping and H3K27 accessibility.

2 citations

humanstructural biology

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BiochemistrybioRxivPreprintJul 31, 2025

Novel insights into the structure and evolution of the human SAGA complex by affinity-ligand purification

Mylène Damilot, Thomas Schoeps, Làszlò Tora…·Adam Ben Shem

This study reports the high-resolution structure of the human SAGA complex, revealing how the SPL module and TAF6L/HEAT repeats are integrated into the complex and their functional implications.

DOI 10.1101/2025.07.31.667873

humanexperimental assay

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Molecular BiologyeLifePeer-reviewedJun 2, 2023

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

Ekaterina Smirnova, Emmanuelle Bignon, Patrick Schultz…·Adam Ben Shem

This study reveals how SIRT6 binds to nucleosomes to position its active site for efficient histone H3 deacetylation.

10 citations

humanChIP-seq

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