Mark A. Landy

Structure of long-range direct and indirect spinocerebellar pathways as well as local spinal circuits mediating proprioception.

The paper defines the anatomical structure of long-range and local proprioceptive circuits in mice, revealing distinct pathways and their functional implications.

Nociceptor subtypes are born continuously over DRG development peaking at E10.5 - E11.5.

The paper determines the birthdates of nociceptor subtypes in mouse DRG neurons, finding continuous birth between E9.5-E13.5 with peak at E10.5-E11.5, and subtype-specific timing.

Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.

This study shows that Prdm12 is essential for nociceptor development but not for adult pain sensation, with distinct transcriptional effects in embryonic and adult dorsal root ganglia.

Motor neurons involved in fine motor control are labeled by tracing Atoh1-lineage neurons in the spinal cord

The paper labels intrinsic hand and foot motor neurons using an Atoh1 CRE knock-in mouse line, showing they have a unique developmental history and can be targeted for functional studies.