Felipe Espinosa

Mycobacterium tuberculosis sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashion

This study shows that Mycobacterium tuberculosis sulfolipid-1 (SL-1) increases TRPV1-positive sensory neuron excitability through Gq/11 pathway activation and intracellular Ca2+ release.

Type I interferons enhance human dorsal root ganglion nociceptor excitability and induce TRPV1 sensitization

This study shows that type I interferons increase excitability of human dorsal root ganglion nociceptors and sensitize TRPV1, contributing to pain.

Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons

This study examines suzetrigine's effects on human dorsal root ganglion neurons, showing it suppresses spontaneous pain-related discharges but requires longer exposure to affect evoked pain.

Electrophysiological properties of neurons in the intermediate thoracolumbar spinal cord mediating proprioception.

The paper compares the electrophysiological properties and sensory input organization of CC and Atoh1-lineage neurons in the thoracolumbar spinal cord, finding distinct firing behaviors and input sources despite both receiving proprioceptive information.

Structure of long-range direct and indirect spinocerebellar pathways as well as local spinal circuits mediating proprioception.

The paper defines the anatomical structure of long-range and local proprioceptive circuits in mice, revealing distinct pathways and their functional implications.

Motor neurons involved in fine motor control are labeled by tracing Atoh1-lineage neurons in the spinal cord

The paper labels intrinsic hand and foot motor neurons using an Atoh1 CRE knock-in mouse line, showing they have a unique developmental history and can be targeted for functional studies.